Anti Acrolein monoclonal antibody: JaICA's OXIDATIVE STRESS MARKERS FOR LIPID PEROXIDATION

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Rev.081024

Anti Acrolein (ACR) monoclonal antibody.

Suitable for immunohistocheistry. For research use only.

Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative. This antibody is specific for the ACR-modified protein, especially FDP-lysine type derivative.

Specifications

Clone #:	5F6
Antigen:	ACR-modified keyhole-lympet hemocyanine
Form:	Frozen (100 µg/mL antibody in 10mM PBS containing 0.1% NaN₃ and 0.5% BSA). Purified by Protein-A.
Application:	Immunohistochemistry. Recommended antibody concentration is 0.5-1.0 µg/mL on paraformaldehyde fixed tissue.
Specificity:	Specific for ACR-modified protein (especially FDP-lysine type derivative)
Subclass:	Mouse IgG_1,kappa
Storage:	Less than -20°C

References

1)	Protein-bound acrolein: Potential markers for oxidativestress. K.Uchida, M.Kanematsu, K.Sakai, T.Matsuda, N.Hattori,Y.Mizuno, D.Suzuki,T.Miyata, N.Noguchi, E.Niki,T.Osawa Proc.Natl.Acad.Sci.USA,95,4882-4887(1998)
2)	Protein-bound acrolein: A novel markers of oxidativestress in Alzheimer's Disease. Noel Y. Calingasan, Koji Uchida, and Gary E.Gibson Journal of Neurochemistry.72(2),751-756(1999)

Product name	Code	Content
Anti Acrolein monoclonal antibody	MAR-020n	20 µg of IgG
Anti Acrolein monoclonal antibody	MAR-100n	unavailable

Manufactured by NOF corporation, Japan.

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to Genox Corporation (Los Angeles, CA).

Instruction manual (PDF)

Technical information

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