Anti MDA(malondialdehyde) monoclonal antibody: JaICA's OXIDATIVE STRESS MARKERS FOR LIPID PEROXIDATION

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Rev.160826

Suitable for immunohistocheistry. For research use only.

About malondialdehyde (MDA)

Malondialdehyde (MDA) is one of the major aldehyde derive from lipid peroxidation. MDA is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with MDA and lysine residue leads to the formation of numerous numbers of adducts, such as dihydropyridine-lysine (DHP-lysine) type derivative. This monoclonal antibody is specific for the MDA-modified protein, especially DHP-lysine type derivative.

Specifications

Clone #:

1F83

Antigen:

MDA-modified keyhole-lympet hemocyanine.

Form:

Frozen (100 µg/mL antibody in 10mM PBS containing 0.1% NaN₃ and 0.5% BSA). Purified by Protein-A.

Application:

Immunohistochemistry.
Recommended antibody concentration is 0.5-1.0 µg/mL on paraformaldehyde fixed tissue.

Specificity:

MSpecific for MDA-modified protein (especially DHP-lysine).

Subclass:

Mouse IgG_2a(lambda)

Storage:

Less than -20°C


Specificity of anti MDA antibody.	Immunohistochemical detection of MDA-modified protein in atherosclerotic aorta. Dr. N Shibata, Tokyo Women's Medical University.

References

1)	Immunochemical detection of a lipofuscin-like fluorophore derivered from malondialdehyde and lysine. S Yamada, S Kumazawa, T Ishii, T Nakayama, K Itakura, N Shibata, M Kobayashi, K Sakai, T Osawa and K Uchida. J.Lipid Res. 42, p1187-1196 (2001)
2)	Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress. Muratori M, Tamburrino L, Marchiani S, Cambi M, Olivito B, Azzari C, Forti G, Baldi E Mol Med. 21,p109-122(2015). doi: 10.2119/molmed.2014.00158.

Product name	Code	Content
Anti Malondialdehyde (MDA) monoclonal antibody	MMD-030n	30 µg IgG

Manufactured by NOF corporation, Japan.

If you are in the U.S., please click here
to Genox Corporation (Los Angeles, CA).

Instruction manual (PDF)

Technical information

[NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.

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