| 1) |
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Circulation 110(15), p2132-2136 (2004): Spiecker M, Darius H, Hankeln T, Soufi M, Sattler AM, Schaefer JR, Node K, Borgel J,
Mugge A, Lindpaintner K, Huesing A, Maisch B, Zeldin DC, Liao JK.
|
| 2) |
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human
tumors. Cancer Res 65(11) ,p4707-4715(2005): Jiang JG, Chen CL, Card JW, Yang S, Chen JX, Fu XN, Ning YG, Xiao X, Zeldin DC, Wang DW.
|
| 3) |
Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after
ischemic injury. J Neurosci 27(17), p4642-4649(2007): Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ.
|
| 4) |
Cytochrome p450 epoxygenase promotes human cancer metastasis.
Cancer Res 67(14), p6665-6674(2007):
Jiang JG, Ning YG, Chen C, Ma D, Liu ZJ, Yang S, Zhou J, Xiao X, Zhang XA, Edin ML, Card JW, Wang J, Zeldin DC, Wang DW.
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| 5) |
Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis
factor-alpha via MAPK and PI3K/Akt signaling pathways.
Am J Physiol Heart Circ Physiol 293(1) ,H142-151(2007):
Yang S, Lin L, Chen JX, Lee CR, Seubert JM, Wang Y, Wang H, Chao ZR, Tao DD, Gong JP, Lu ZY, Wang DW, Zeldin DC.
|
| 6) |
Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.
Stroke 39(7), p2073-2078(2008):
doi: 10.1161/STROKEAHA.107.508325
Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ.
マウス脳における14,15-EET検出例です。野生型マウスについて、483 pg/ 50mg tissueと報告されています。
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| 7) |
Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers
in vitro and in vivo. J Pharmacol Exp Ther 329(3), p908-918(2009):
Chen C, Li G, Liao W, Wu J, Liu L, Ma D, Zhou J, Elbekai RH, Edin ML, Zeldin DC, Wang DW.
|
| 8) |
Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of
premature myocardial infarction. Atherosclerosis 195(1), p199-206(2007):
Liu PY, Li YH, Chao TH, Wu HL, Lin LJ, Tsai LM, Chen JH.
|
| 9) |
Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.
J Cereb Blood Flow Metab 29(8), p1475-1481(2009): Zhang W, Iliff JJ, Campbell CJ, Wang RK, Hurn PD, Alkayed NJ.
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